Theaimis to summarize current knowledge on bothQoL and depressive/anxious symptoms in patients with UM, including studies\non the effect on QoL and psychological status of genetic testing related to the risk of metastatic disease. A review from the last 25\nyears by using the databases ââ?¬Å?PsycInfo,ââ?¬Â ââ?¬Å?Medline,ââ?¬Â and ââ?¬Å?Science Directââ?¬Â was performed. As a total result, eighteen papers were\nretrieved. Eight studies (44.4%) used a prospective design methodology: two were retrospective observations (11.1%), three were\ncross-sectional observational studies (16.6%), and three (16.6%) were naturalistic follow-up studies. One trial was conducted with\na case-control design (5.5%), and one was a methodological paper (5.5%). The number of subjects included in the studies ranged\nwidely, between 7 and 842 (mean: 152.1 Ã?± 201.3), for a total of 2587 patients, 1306 males (50.5%) and 1281 females (49.5%).Themean\nage of subject enrolled was 61.3 Ã?± 4.1 years. Twenty-six different scales, questionnaires, or interviews were utilized. No significant\ndifferences inQoL between radiotherapy and enucleation emerged.Genetic testing did not significantly affectQoL or psychological\nstatus.
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